8b42
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of heteromeric LRRC8A/C Volume-Regulated Anion Channel== | |
| - | + | <StructureSection load='8b42' size='340' side='right'caption='[[8b42]], [[Resolution|resolution]] 6.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8b42]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B42 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b42 OCA], [https://pdbe.org/8b42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b42 RCSB], [https://www.ebi.ac.uk/pdbsum/8b42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b42 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Dutzler R]] | ||
| + | [[Category: Sawicka M]] | ||
Revision as of 10:08, 14 December 2022
Structure of heteromeric LRRC8A/C Volume-Regulated Anion Channel
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