[[https://www.uniprot.org/uniprot/APN2_YEAST APN2_YEAST]] DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA.<ref>PMID:10806210</ref> <ref>PMID:9765213</ref>
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[https://www.uniprot.org/uniprot/APN2_YEAST APN2_YEAST] DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA.<ref>PMID:10806210</ref> <ref>PMID:9765213</ref>
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==See Also==
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*[[Apurinic/apyrimidinic endonuclease 3D structures|Apurinic/apyrimidinic endonuclease 3D structures]]
== References ==
== References ==
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Revision as of 19:29, 19 October 2022
Crystal Structure of Saccharomyces cerevisiae Apn2 Catalytic Domain E59Q/D222N Mutant in Complex with DNA
APN2_YEAST DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA.[1][2]
↑ Unk I, Haracska L, Johnson RE, Prakash S, Prakash L. Apurinic endonuclease activity of yeast Apn2 protein. J Biol Chem. 2000 Jul 21;275(29):22427-34. PMID:10806210 doi:http://dx.doi.org/10.1074/jbc.M002845200
↑ Johnson RE, Torres-Ramos CA, Izumi T, Mitra S, Prakash S, Prakash L. Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes Dev. 1998 Oct 1;12(19):3137-43. doi: 10.1101/gad.12.19.3137. PMID:9765213 doi:http://dx.doi.org/10.1101/gad.12.19.3137
