1iiz

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{{STRUCTURE_1iiz| PDB=1iiz | SCENE= }}
{{STRUCTURE_1iiz| PDB=1iiz | SCENE= }}
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'''Crystal Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antheraea mylitta'''
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===Crystal Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antheraea mylitta===
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==Overview==
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The crystal structure of an antibacterial protein of immune origin (TSWAB), purified from tasar silkworm (Antheraea mylitta) larvae after induction by Escherichia coli infection, has been determined. This is the first insect lysozyme structure and represents induced lysozymes of innate immunity. The core structure of TSWAB is similar to c-type lysozymes and alpha-lactalbumins. However, TSWAB shows significant differences with respect to the other two proteins in the exposed loop regions. The catalytic residues in TSWAB are conserved with respect to the chicken lysozyme, indicating a common mechanism of action. However, differences in the noncatalytic residues in the substrate binding groove imply subtle differences in the specificity and the level of activity. Thus, conformational differences between TSWAB and chicken lysozyme exist, whereas functional mechanisms appear to be similar. On the other hand, alpha-lactalbumins and c-type lysozymes exhibit drastically different functions with conserved molecular conformation. It is evident that a common molecular scaffold is exploited in the three enzymes for apparently different physiological roles. It can be inferred on the basis of the structure-function comparison of these three proteins having common phylogenetic origin that the conformational changes in a protein are minimal during rapid evolution as compared with those in the normal course of evolution.
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(as it appears on PubMed at http://www.pubmed.gov), where 11522783 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11522783}}
==About this Structure==
==About this Structure==
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[[Category: Swaminathan, G J.]]
[[Category: Swaminathan, G J.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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Revision as of 09:18, 1 July 2008

Image:1iiz.png

Template:STRUCTURE 1iiz

Crystal Structure of the Induced Antibacterial Protein from Tasar Silkworm, Antheraea mylitta

Template:ABSTRACT PUBMED 11522783

About this Structure

1IIZ is a Single protein structure of sequence from Antheraea mylitta. Full crystallographic information is available from OCA.

Reference

Structure of the induced antibacterial protein from tasar silkworm, Antheraea mylitta. Implications to molecular evolution., Jain D, Nair DT, Swaminathan GJ, Abraham EG, Nagaraju J, Salunke DM, J Biol Chem. 2001 Nov 2;276(44):41377-82. Epub 2001 Aug 24. PMID:11522783

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