1ij2

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[[Image:1ij2.jpg|left|200px]]
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{{Seed}}
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[[Image:1ij2.png|left|200px]]
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{{STRUCTURE_1ij2| PDB=1ij2 | SCENE= }}
{{STRUCTURE_1ij2| PDB=1ij2 | SCENE= }}
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'''GCN4-pVTL Coiled-coil Trimer with Threonine at the a(16) position'''
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===GCN4-pVTL Coiled-coil Trimer with Threonine at the a(16) position===
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==Overview==
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Coiled coils, estimated to constitute 3-5% of the encoded residues in most genomes, are characterized by a heptad repeat, (abcdefg)(n), where the buried a and d positions form the interface between multiple alpha-helices. Although generally hydrophobic, a substantial fraction ( approximately 20%) of these a- and d-position residues are polar or charged. We constructed variants of the well-characterized coiled coil GCN4-p1 with a single polar residue (Asn, Gln, Ser, or Thr) at either an a or a d position. The stability and oligomeric specificity of each variant were measured, and crystal structures of coiled-coil trimers with threonine or serine at either an a or a d position were determined. The structures show how single polar residues in the interface affect not only local packing, but also overall coiled-coil geometry as seen by changes in the Crick supercoil parameters and core cavity volumes.
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The line below this paragraph, {{ABSTRACT_PUBMED_11371197}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11371197 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11371197}}
==About this Structure==
==About this Structure==
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[[Category: Malashkevich, V N.]]
[[Category: Malashkevich, V N.]]
[[Category: Gcn4 coiled coil]]
[[Category: Gcn4 coiled coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:03:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:18:17 2008''

Revision as of 09:18, 1 July 2008

Image:1ij2.png

Template:STRUCTURE 1ij2

GCN4-pVTL Coiled-coil Trimer with Threonine at the a(16) position

Template:ABSTRACT PUBMED 11371197

About this Structure

1IJ2 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Buried polar residues in coiled-coil interfaces., Akey DL, Malashkevich VN, Kim PS, Biochemistry. 2001 May 29;40(21):6352-60. PMID:11371197

Page seeded by OCA on Tue Jul 1 12:18:17 2008

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