1gux
From Proteopedia
(New page: 200px<br /> <applet load="1gux" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gux, resolution 1.85Å" /> '''RB POCKET BOUND TO ...) |
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| - | [[Image:1gux.gif|left|200px]]<br /> | + | [[Image:1gux.gif|left|200px]]<br /><applet load="1gux" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1gux" size=" | + | |
caption="1gux, resolution 1.85Å" /> | caption="1gux, resolution 1.85Å" /> | ||
'''RB POCKET BOUND TO E7 LXCXE MOTIF'''<br /> | '''RB POCKET BOUND TO E7 LXCXE MOTIF'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The pocket domain of the retinoblastoma (Rb) tumour suppressor is central | + | The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B-box portion of the pocket; the A-box portion appears to be required for the stable folding of the B box. Also highly conserved is the extensive A-B interface, suggesting that it may be an additional protein-binding site. The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GUX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http:// | + | 1GUX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Human papillomavirus]] | [[Category: Human papillomavirus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Lee, J | + | [[Category: Lee, J O.]] |
| - | [[Category: Pavletich, N | + | [[Category: Pavletich, N P.]] |
| - | [[Category: Russo, A | + | [[Category: Russo, A A.]] |
[[Category: complex (transcription regulation/peptide)]] | [[Category: complex (transcription regulation/peptide)]] | ||
[[Category: retinoblastoma]] | [[Category: retinoblastoma]] | ||
[[Category: tumor suppressor protein]] | [[Category: tumor suppressor protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:54:14 2008'' |
Revision as of 10:54, 21 February 2008
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RB POCKET BOUND TO E7 LXCXE MOTIF
Contents |
Overview
The pocket domain of the retinoblastoma (Rb) tumour suppressor is central to Rb function, and is frequently inactivated by the binding of the human papilloma virus E7 oncoprotein in cervical cancer. The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B-box portion of the pocket; the A-box portion appears to be required for the stable folding of the B box. Also highly conserved is the extensive A-B interface, suggesting that it may be an additional protein-binding site. The A and B boxes each contain the cyclin-fold structural motif, with the LxCxE-binding site on the B-box cyclin fold being similar to a Cdk2-binding site of cyclin A and to a TBP-binding site of TFIIB.
Disease
Known diseases associated with this structure: Bladder cancer OMIM:[180200], Osteosarcoma OMIM:[180200], Pinealoma with bilateral retinoblastoma OMIM:[180200], Retinoblastoma OMIM:[180200]
About this Structure
1GUX is a Protein complex structure of sequences from Homo sapiens and Human papillomavirus. Full crystallographic information is available from OCA.
Reference
Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7., Lee JO, Russo AA, Pavletich NP, Nature. 1998 Feb 26;391(6670):859-65. PMID:9495340
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