1ij6

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{{STRUCTURE_1ij6| PDB=1ij6 | SCENE= }}
{{STRUCTURE_1ij6| PDB=1ij6 | SCENE= }}
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'''CA2+-BOUND STRUCTURE OF MULTIDOMAIN EF-HAND PROTEIN, CBP40, FROM TRUE SLIME MOLD'''
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===CA2+-BOUND STRUCTURE OF MULTIDOMAIN EF-HAND PROTEIN, CBP40, FROM TRUE SLIME MOLD===
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==Overview==
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Acellular slime mold, Physarum polycephalum, has a unique wound-healing system. When cytoplasm of plasmodia is exposed to extracellular fluid, calcium binding protein 40 (CBP40) seals damaged areas, forming large aggregates Ca(2+) dependently. Part of the CBP40 is truncated at the N terminus by a proteinase in plasmodia (CBP40delta), which does not aggregate in the Ca(2+)-bound form. Here we report the crystal structures of CBP40delta in both the metal-free and the Ca(2+)-bound states. Both structures consist of three domains: coiled-coil, intervening, and EF-hand. The topology of the EF-hand domain is similar to that of calpain. The N-terminal half of CBP40Delta interacts with the C-terminal EF-hands through a large hydrophobic interface, necessary for high Ca(2+) affinity. Conformational change upon Ca(2+) binding is small; however, the structure of CBP40delta provides novel insights into the mechanism of Ca(2+)-dependent oligomerization.
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(as it appears on PubMed at http://www.pubmed.gov), where 12517342 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12517342}}
==About this Structure==
==About this Structure==
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[[Category: Cbp40]]
[[Category: Cbp40]]
[[Category: Fourty kda calcium binding protein]]
[[Category: Fourty kda calcium binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:03:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:18:38 2008''

Revision as of 09:18, 1 July 2008

Image:1ij6.png

Template:STRUCTURE 1ij6

CA2+-BOUND STRUCTURE OF MULTIDOMAIN EF-HAND PROTEIN, CBP40, FROM TRUE SLIME MOLD

Template:ABSTRACT PUBMED 12517342

About this Structure

1IJ6 is a Single protein structure of sequence from Physarum polycephalum. Full crystallographic information is available from OCA.

Reference

Metal-free and Ca2+-bound structures of a multidomain EF-hand protein, CBP40, from the lower eukaryote Physarum polycephalum., Iwasaki W, Sasaki H, Nakamura A, Kohama K, Tanokura M, Structure. 2003 Jan;11(1):75-85. PMID:12517342

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