1ijb

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[[Image:1ijb.jpg|left|200px]]
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{{STRUCTURE_1ijb| PDB=1ijb | SCENE= }}
{{STRUCTURE_1ijb| PDB=1ijb | SCENE= }}
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'''The von Willebrand Factor mutant (I546V) A1 domain'''
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===The von Willebrand Factor mutant (I546V) A1 domain===
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==Overview==
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The A1 domain of von Willebrand factor (vWF) mediates platelet adhesion to sites of vascular injury by binding to the platelet receptor glycoprotein Ib (GpIb), an interaction that is regulated by hydrodynamic shear forces. The GpIb binding surface of A1 is distinct from a regulatory region, suggesting that ligand binding is controlled allosterically. Here we report the crystal structures of the "gain-of-function" mutant A1 domain (I546V) and its complex with the exogenous activator botrocetin. We show that botrocetin switches the mutant A1 back toward the wild-type conformation, suggesting that affinity is enhanced by augmenting the GpIb binding surface rather than through allosteric control. Functional studies of platelet adhesion under flow further suggest that the activation mechanism is distinct from that of the gain-of-function mutation.
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(as it appears on PubMed at http://www.pubmed.gov), where 12121649 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12121649}}
==About this Structure==
==About this Structure==
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[[Category: Liddington, R C.]]
[[Category: Liddington, R C.]]
[[Category: Dinucleotide-binding fold]]
[[Category: Dinucleotide-binding fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:19:24 2008''

Revision as of 09:19, 1 July 2008

Image:1ijb.png

Template:STRUCTURE 1ijb

The von Willebrand Factor mutant (I546V) A1 domain

Template:ABSTRACT PUBMED 12121649

About this Structure

1IJB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of von Willebrand factor activation by the snake toxin botrocetin., Fukuda K, Doggett TA, Bankston LA, Cruz MA, Diacovo TG, Liddington RC, Structure. 2002 Jul;10(7):943-50. PMID:12121649

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