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1ije

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{{STRUCTURE_1ije| PDB=1ije | SCENE= }}
{{STRUCTURE_1ije| PDB=1ije | SCENE= }}
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'''Nucleotide Exchange Intermediates in the eEF1A-eEF1Ba Complex'''
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===Nucleotide Exchange Intermediates in the eEF1A-eEF1Ba Complex===
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==Overview==
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In the elongation cycle of protein biosynthesis, the nucleotide exchange factor eEF1Balpha catalyzes the exchange of GDP bound to the G-protein, eEF1A, for GTP. To obtain more information about the recently solved eEF1A-eEF1Balpha structure, we determined the structures of the eEF1A-eEF1Balpha-GDP-Mg2+, eEF1A-eEF1Balpha-GDP and eEF1A-eEF1Balpha-GDPNP complexes at 3.0, 2.4 and 2.05 A resolution, respectively. Minor changes, specifically around the nucleotide binding site, in eEF1A and eEF1Balpha are consistent with in vivo data. The base, sugar and alpha-phosphate bind as in other known nucleotide G-protein complexes, whereas the beta- and gamma-phosphates are disordered. A mutation of Lys 205 in eEF1Balpha that inserts into the Mg2+ binding site of eEF1A is lethal. This together with the structures emphasizes the essential role of Mg2+ in nucleotide exchange in the eEF1A-eEF1Balpha complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 11373622 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11373622}}
==About this Structure==
==About this Structure==
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[[Category: Valente, L.]]
[[Category: Valente, L.]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:03:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:19:51 2008''

Revision as of 09:19, 1 July 2008

Image:1ije.png

Template:STRUCTURE 1ije

Nucleotide Exchange Intermediates in the eEF1A-eEF1Ba Complex

Template:ABSTRACT PUBMED 11373622

About this Structure

1IJE is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex., Andersen GR, Valente L, Pedersen L, Kinzy TG, Nyborg J, Nat Struct Biol. 2001 Jun;8(6):531-4. PMID:11373622

Page seeded by OCA on Tue Jul 1 12:19:51 2008

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