1ijl

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[[Image:1ijl.jpg|left|200px]]
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{{Seed}}
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[[Image:1ijl.png|left|200px]]
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{{STRUCTURE_1ijl| PDB=1ijl | SCENE= }}
{{STRUCTURE_1ijl| PDB=1ijl | SCENE= }}
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'''Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus'''
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===Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus===
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==Overview==
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An acidic phospholipase A(2) was purified from Deinagkistrodon acutus (Agkistrodon acutus) which displays an inhibitory effect on platelet aggregation. The three-dimensional structure of the enzyme was determined by molecular replacement at 2.6 A resolution with a crystallographic R factor of 18.40% (R(free) = 22.50%) and reasonable stereochemistry. Two molecules in the asymmetric unit form a dimer and the dimer formation accompanies a significant conformational adaptation of segment 14-23, a constituent of the 'interface recognition site' (IRS). This probably reflects the inherent structural flexibility of the IRS. The possible expansion of the site for inhibiting platelet aggregation as proposed previously [Wang et al. (1996), J. Mol. Biol. 255, 669-676] is discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_11752784}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11752784 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11752784}}
==About this Structure==
==About this Structure==
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[[Category: One two strand beta sheet]]
[[Category: One two strand beta sheet]]
[[Category: Three long helix]]
[[Category: Three long helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:04:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:22:02 2008''

Revision as of 09:22, 1 July 2008

Image:1ijl.png

Template:STRUCTURE 1ijl

Crystal structure of acidic phospholipase A2 from deinagkistrodon acutus

Template:ABSTRACT PUBMED 11752784

About this Structure

1IJL is a Single protein structure of sequence from Deinagkistrodon acutus. Full crystallographic information is available from OCA.

Reference

Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus., Gu L, Zhang H, Song S, Zhou Y, Lin Z, Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):104-10. Epub 2001, Dec 21. PMID:11752784

Page seeded by OCA on Tue Jul 1 12:22:02 2008

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