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4e61

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Current revision (11:02, 1 March 2024) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4e61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E61 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4e61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E61 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e61 OCA], [https://pdbe.org/4e61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e61 RCSB], [https://www.ebi.ac.uk/pdbsum/4e61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e61 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e61 OCA], [https://pdbe.org/4e61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e61 RCSB], [https://www.ebi.ac.uk/pdbsum/4e61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e61 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BIM1_YEAST BIM1_YEAST]] Binds microtubules.
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[https://www.uniprot.org/uniprot/BIM1_YEAST BIM1_YEAST] Binds microtubules.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mitosis begins with the tethering of chromosomes to the mitotic spindle and their orientation perpendicular to the axis of cell division. In budding yeast, mitotic spindle orientation and the subsequent chromosome segregation are two independent processes. Early spindle orientation is driven by the actin-bound myosin Myo2p, which interacts with the adapter Kar9p. The latter also binds to microtubule-associated Bim1p, thereby connecting both types of cytoskeleton. This study focuses on the interaction between Kar9p and Bim1p and its regulation. We solved the crystal structure of the previously reported Kar9p-binding motif of Bim1p and identified a second, novel Kar9p-interaction domain. We further show that two independent posttranslational modification events regulate their interaction. Whereas Kar9p sumoylation is required for efficient complex formation with Bim1p, Aurora B/Ipl1p-dependent phosphorylation of Bim1p down-regulates their interaction. The observed effects of these modifications allow us to propose a novel regulatory framework for the assembly and disassembly of the early spindle-orientation complex.
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Posttranslational modifications regulate assembly of the early spindle-orientation complex in yeast.,Huls D, Storchova Z, Niessing D J Biol Chem. 2012 Mar 29. PMID:22461628<ref>PMID:22461628</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4e61" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>

Current revision

Crystal structure of the EB1-like motif of Bim1p

PDB ID 4e61

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