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1ilp

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[[Image:1ilp.gif|left|200px]]
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{{STRUCTURE_1ilp| PDB=1ilp | SCENE= }}
{{STRUCTURE_1ilp| PDB=1ilp | SCENE= }}
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'''CXCR-1 N-TERMINAL PEPTIDE BOUND TO INTERLEUKIN-8'''
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===CXCR-1 N-TERMINAL PEPTIDE BOUND TO INTERLEUKIN-8===
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==Overview==
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BACKGROUND: Interactions between CXC chemokines (e.g. interleukin-8, IL-8) and their receptors (e.g. CXCR-1) have a key role in host defense and disease by attracting and upregulating neutrophils to sites of inflammation. The transmembrane nature of the receptor impedes structure-based understanding of ligand interactions. Linear peptides based on the N-terminal, extracellular portion of the receptor CXCR-1 do bind to IL-8, however, and inhibit the binding of IL-8 to the full-length receptor. RESULTS: The NMR solution structure of the complex formed between IL-8 and one such receptor-based peptide indicates that a cleft between a loop and a beta hairpin constitute part of the receptor interaction surface on IL-8. Nine residues from the C terminus of the receptor peptide (corresponding to Pro21-Pro29 of CXCR-1) occupy the cleft in an extended fashion. Intermolecular contacts are mostly hydrophobic and sidechain mediated. CONCLUSIONS: The results offer the first details at an atomic level of the interaction between a chemokine and its receptor. Consideration of other biochemical data allow extrapolation to a model for the interaction of IL-8 with the full-length receptor. In this model, the heparin-binding residues of IL-8 are exposed, thereby allowing presentation of the chemokine from endothelial cell-surface glycosaminoglycans. This first glimpse of how IL-8 binds to its receptor provides a foundation for the structure-based design of chemokine antagonists.
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(as it appears on PubMed at http://www.pubmed.gov), where 10368283 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10368283}}
==About this Structure==
==About this Structure==
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1ILP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ILP OCA].
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1ILP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ILP OCA].
==Reference==
==Reference==
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[[Category: Skelton, N J.]]
[[Category: Skelton, N J.]]
[[Category: Cytokine]]
[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:07:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:28:20 2008''

Revision as of 10:28, 1 July 2008

Image:1ilp.png

Template:STRUCTURE 1ilp

CXCR-1 N-TERMINAL PEPTIDE BOUND TO INTERLEUKIN-8

Template:ABSTRACT PUBMED 10368283

About this Structure

1ILP is a Protein complex structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of a CXC chemokine-receptor fragment in complex with interleukin-8., Skelton NJ, Quan C, Reilly D, Lowman H, Structure. 1999 Feb 15;7(2):157-68. PMID:10368283

Page seeded by OCA on Tue Jul 1 13:28:20 2008

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