1imi

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[[Image:1imi.gif|left|200px]]
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{{STRUCTURE_1imi| PDB=1imi | SCENE= }}
{{STRUCTURE_1imi| PDB=1imi | SCENE= }}
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'''SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1'''
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===SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1===
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==Overview==
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A 600 MHz NMR study of alpha-conotoxin ImI from Conus imperialis, targeting the alpha7 neuronal nicotinic acetylcholine receptor (nAChR), is presented. ImI backbone spatial structure is well defined basing on the NOEs, spin-spin coupling constants, and amide protons hydrogen-deuterium exchange data: rmsd of the backbone atom coordinates at the 2-12 region is 0.28 A in the 20 best structures. The structure is described as a type I beta-turn (positions 2-5) followed by a distorted helix (positions 5-11). Similar structural patterns can be found in all neuronal-specific alpha-conotoxins. Highly mobile side chains of the Asp-5, Arg-7 and Trp-10 residues form a single site for ImI binding to the alpha7 receptor. When depicted with opposite directions of the polypeptide chains, the ImI helix and the tip of the central loop of long chain snake neurotoxins demonstrate a common scaffold and similar positioning of the functional side chains, both of these structural elements appearing essential for binding to the neuronal nAChRs.
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(as it appears on PubMed at http://www.pubmed.gov), where 10050774 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10050774}}
==About this Structure==
==About this Structure==
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1IMI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMI OCA].
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1IMI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMI OCA].
==Reference==
==Reference==
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[[Category: Nicotinic acetylcholine receptor]]
[[Category: Nicotinic acetylcholine receptor]]
[[Category: Postsynaptic]]
[[Category: Postsynaptic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:09:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:32:41 2008''

Revision as of 10:32, 1 July 2008

Image:1imi.png

Template:STRUCTURE 1imi

SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1

Template:ABSTRACT PUBMED 10050774

About this Structure

1IMI is a Single protein structure of sequence from Conus imperialis. Full experimental information is available from OCA.

Reference

NMR spatial structure of alpha-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors., Maslennikov IV, Shenkarev ZO, Zhmak MN, Ivanov VT, Methfessel C, Tsetlin VI, Arseniev AS, FEBS Lett. 1999 Feb 12;444(2-3):275-80. PMID:10050774

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