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1imt

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{{STRUCTURE_1imt| PDB=1imt | SCENE= }}
{{STRUCTURE_1imt| PDB=1imt | SCENE= }}
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'''MAMBA INTESTINAL TOXIN 1, NMR, 39 STRUCTURES'''
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===MAMBA INTESTINAL TOXIN 1, NMR, 39 STRUCTURES===
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==Overview==
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The solution structure of mamba intestinal toxin 1 (MIT1), isolated from Dendroaspis polylepis polylepis venom, has been determined. This molecule is a cysteine-rich polypeptide exhibiting no recognised family membership. Resistance to MIT1 to classical specific endoproteases produced contradictory NMR and biochemical information concerning disulphide-bridge topology. We have used distance restraints allowing ambiguous partners between S atoms in combination with NMR-derived structural information, to correctly determine the disulphide-bridge topology. The resultant solution structure of MIT1, determined to a resolution of 0.5 A, reveals an unexpectedly similar global fold with respect to colipase, a protein involved in fatty acid digestion. Colipase exhibits an analogous resistance to endoprotease activity, indicating for the first time the possible topological origins of this biochemical property. The biochemical and structural homology permitted us to propose a mechanically related digestive function for MIT1 and provides novel information concerning snake venom protein evolution.
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{{ABSTRACT_PUBMED_9761684}}
==About this Structure==
==About this Structure==
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1IMT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMT OCA].
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1IMT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMT OCA].
==Reference==
==Reference==
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[[Category: Toxin]]
[[Category: Toxin]]
[[Category: Venom]]
[[Category: Venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:33:59 2008''

Revision as of 10:34, 1 July 2008

Image:1imt.png

Template:STRUCTURE 1imt

MAMBA INTESTINAL TOXIN 1, NMR, 39 STRUCTURES

Template:ABSTRACT PUBMED 9761684

About this Structure

1IMT is a Single protein structure of sequence from Dendroaspis polylepis polylepis. Full experimental information is available from OCA.

Reference

A structural homologue of colipase in black mamba venom revealed by NMR floating disulphide bridge analysis., Boisbouvier J, Albrand JP, Blackledge M, Jaquinod M, Schweitz H, Lazdunski M, Marion D, J Mol Biol. 1998;283(1):205-19. PMID:9761684

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