1imu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1imu.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1imu.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1imu| PDB=1imu | SCENE= }}
{{STRUCTURE_1imu| PDB=1imu | SCENE= }}
-
'''Solution Structure of HI0257, a Ribosome Binding Protein'''
+
===Solution Structure of HI0257, a Ribosome Binding Protein===
-
==Overview==
+
<!--
-
A novel bacterial ribosome binding protein, protein Y (also known as YfiA), was recently shown to reside at the 30S/50S subunit interface and to stabilize the ribosomal 70S complex against dissociation at low magnesium ion concentrations. We report here the three-dimensional NMR structure in solution of a homologue from Haemophilus influenzae, HI0257, that has 64% sequence identity to protein Y. The 107 residue protein has a beta-alpha-beta-beta-beta-alpha folding topology with two parallel alpha-helices packed against the same side of a four-stranded beta-sheet. The closest structural relatives are proteins with the double-stranded RNA-binding domain (dsRBD) motif although there is little (&lt;10%) sequence homology. The most immediate differences between the dsRBD and HI0257 structures are that (1) HI0257 has a larger beta-sheet motif with an extra beta-strand at the N-terminus, (2) the helices are parallel in HI0257 but at an angle of about 30 degrees to each other in the dsRBD, and (3) HI0257 lacks the extended loop commonly seen between the first and second beta-strands of the dsRBD. Further, an analysis of the surface electrostatic potential in HI0257 and the dsRBD family reveals significant differences in the location of contiguous positively (and negatively) charged regions. The structural data, in combination with sequence analysis of HI0257 and its homologues, suggest that the most likely mode of RNA recognition for HI0257 may be distinct from that of the dsRBD family of proteins.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11551193}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11551193 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11551193}}
==About this Structure==
==About this Structure==
-
1IMU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMU OCA].
+
1IMU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMU OCA].
==Reference==
==Reference==
Line 34: Line 38:
[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structure 2 function project]]
[[Category: Structure 2 function project]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:10:10 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:34:16 2008''

Revision as of 10:34, 1 July 2008

Image:1imu.png

Template:STRUCTURE 1imu

Solution Structure of HI0257, a Ribosome Binding Protein

Template:ABSTRACT PUBMED 11551193

About this Structure

1IMU is a Single protein structure of sequence from Haemophilus influenzae. Full experimental information is available from OCA.

Reference

Solution structure of HI0257, a bacterial ribosome binding protein., Parsons L, Eisenstein E, Orban J, Biochemistry. 2001 Sep 18;40(37):10979-86. PMID:11551193

Page seeded by OCA on Tue Jul 1 13:34:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1imu"
Personal tools