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1inq

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{{STRUCTURE_1inq| PDB=1inq | SCENE= }}
{{STRUCTURE_1inq| PDB=1inq | SCENE= }}
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'''Structure of Minor Histocompatibility Antigen peptide, H13a, complexed to H2-Db'''
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===Structure of Minor Histocompatibility Antigen peptide, H13a, complexed to H2-Db===
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==Overview==
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The mouse H13 minor histocompatibility (H) Ag, originally detected as a barrier to allograft transplants, is remarkable in that rejection is a consequence of an extremely subtle interchange, P4(Val/Ile), in a nonamer H2-D(b)-bound peptide. Moreover, H13 peptides lack the canonical P5(Asn) central anchor residue normally considered important for forming a peptide/MHC complex. To understand how these noncanonical peptide pMHC complexes form physiologically active TCR ligands, crystal structures of allelic H13 pD(b) complexes and a P5(Asn) anchored pD(b) analog were solved to high resolution. The structures show that the basis of TCRs to distinguish self from nonself H13 peptides is their ability to distinguish a single solvent-exposed methyl group. In addition, the structures demonstrate that there is no need for H13 peptides to derive any stabilization from interactions within the central C pocket to generate fully functional pMHC complexes. These results provide a structural explanation for a classical non-MHC-encoded H Ag, and they call into question the requirement for contact between anchor residues and the major MHC binding pockets in vaccine design.
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The line below this paragraph, {{ABSTRACT_PUBMED_11751972}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11751972 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11751972}}
==About this Structure==
==About this Structure==
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[[Category: Mhc complex]]
[[Category: Mhc complex]]
[[Category: Minor histocompatibility antigen]]
[[Category: Minor histocompatibility antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:11:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:37:35 2008''

Revision as of 10:37, 1 July 2008

Image:1inq.png

Template:STRUCTURE 1inq

Structure of Minor Histocompatibility Antigen peptide, H13a, complexed to H2-Db

Template:ABSTRACT PUBMED 11751972

About this Structure

1INQ is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination., Ostrov DA, Roden MM, Shi W, Palmieri E, Christianson GJ, Mendoza L, Villaflor G, Tilley D, Shastri N, Grey H, Almo SC, Roopenian D, Nathenson SG, J Immunol. 2002 Jan 1;168(1):283-9. PMID:11751972

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