8b10
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Shank2-SAM mutant domain - L1800W== | |
| - | + | <StructureSection load='8b10' size='340' side='right'caption='[[8b10]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8b10]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B10 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b10 OCA], [https://pdbe.org/8b10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b10 RCSB], [https://www.ebi.ac.uk/pdbsum/8b10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b10 ProSAT]</span></td></tr> |
| - | [[Category: Bento | + | </table> |
| - | [[Category: Gracia Alai | + | == Disease == |
| - | [[Category: Kreienkamp | + | [https://www.uniprot.org/uniprot/SHAN2_HUMAN SHAN2_HUMAN] NON RARE IN EUROPE: Autism. Disease susceptibility is associated with variants affecting the gene represented in this entry. |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SHAN2_HUMAN SHAN2_HUMAN] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bento I]] | ||
| + | [[Category: Gracia Alai M]] | ||
| + | [[Category: Kreienkamp J-H]] | ||
Revision as of 10:45, 30 November 2022
Crystal Structure of Shank2-SAM mutant domain - L1800W
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