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8edk
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of C. elegans UNC-6 LamN and EGF domains== | |
| - | + | <StructureSection load='8edk' size='340' side='right'caption='[[8edk]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8edk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EDK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8edk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8edk OCA], [https://pdbe.org/8edk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8edk RCSB], [https://www.ebi.ac.uk/pdbsum/8edk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8edk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/UNC6_CAEEL UNC6_CAEEL] Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis (PubMed:8861903). Required for the guidance of pioneer axons and migrating cells along the body wall (PubMed:8332188, PubMed:28846083). In particular, it is required for the guidance of axons from neurons, including SubL neurons and AIY interneurons, into the nerve ring (PubMed:28846083, PubMed:9473333). During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms (PubMed:22732572, PubMed:17716643). Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively (PubMed:8332188, PubMed:8861903, PubMed:9473333). Involved in dendritic morphogenesis; may act by association with unc-40 at the tips of growing dendrites for interaction with unc-5 on the apposing branch to induce mutual repulsion (PubMed:22426253). Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail (PubMed:24004945). Required for the formation of synapses between the AVA interneurons and the PHB sensory neurons (PubMed:29742100).<ref>PMID:17716643</ref> <ref>PMID:22426253</ref> <ref>PMID:22732572</ref> <ref>PMID:24004945</ref> <ref>PMID:28846083</ref> <ref>PMID:29742100</ref> <ref>PMID:8332188</ref> <ref>PMID:8861903</ref> <ref>PMID:9473333</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Caenorhabditis elegans]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ozkan E]] | ||
| + | [[Category: Priest JM]] | ||
Revision as of 07:42, 11 January 2023
Structure of C. elegans UNC-6 LamN and EGF domains
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