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8efq

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'''Unreleased structure'''
 
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The entry 8efq is ON HOLD until Paper Publication
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==DAMGO-bound mu-opioid receptor-Gi complex==
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<StructureSection load='8efq' size='340' side='right'caption='[[8efq]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors: Zhuang, Y., Wang, Y., Guo, S., Zhou, X.E., Rao, Q., He, X., He, B., Liu, J., Zhou, Q., Wang, X., Liu, W., Jiang, X., Yang, D., Chen, X., Jiang, Y., Jiang, H., Shen, J., Melcher, K., Wang, M., Xie, X., Xu, H.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8efq]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EFQ FirstGlance]. <br>
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Description: DAMGO-bound mu-opioid receptor-Gi complex
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=MEA:N-METHYLPHENYLALANINE'>MEA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8efq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8efq OCA], [https://pdbe.org/8efq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8efq RCSB], [https://www.ebi.ac.uk/pdbsum/8efq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8efq ProSAT]</span></td></tr>
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[[Category: Wang, M]]
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</table>
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[[Category: Zhou, X.E]]
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== Function ==
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[[Category: Xu, H.E]]
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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[[Category: Melcher, K]]
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== References ==
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[[Category: He, X]]
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<references/>
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[[Category: Chen, X]]
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__TOC__
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[[Category: Yang, D]]
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</StructureSection>
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[[Category: Liu, W]]
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[[Category: Bos taurus]]
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[[Category: Guo, S]]
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[[Category: Homo sapiens]]
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[[Category: He, B]]
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[[Category: Large Structures]]
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[[Category: Jiang, Y]]
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[[Category: Rattus norvegicus]]
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[[Category: Wang, Y]]
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[[Category: Synthetic construct]]
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[[Category: Xie, X]]
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[[Category: Chen X]]
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[[Category: Zhuang, Y]]
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[[Category: Guo S]]
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[[Category: Zhou, Q]]
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[[Category: He B]]
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[[Category: Jiang, H]]
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[[Category: He X]]
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[[Category: Liu, J]]
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[[Category: Jiang H]]
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[[Category: Wang, X]]
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[[Category: Jiang X]]
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[[Category: Shen, J]]
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[[Category: Jiang Y]]
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[[Category: Jiang, X]]
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[[Category: Liu J]]
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[[Category: Rao, Q]]
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[[Category: Liu W]]
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[[Category: Melcher K]]
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[[Category: Rao Q]]
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[[Category: Shen J]]
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[[Category: Wang M]]
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[[Category: Wang X]]
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[[Category: Wang Y]]
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[[Category: Xie X]]
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[[Category: Xu HE]]
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[[Category: Yang D]]
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[[Category: Zhou Q]]
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[[Category: Zhou XE]]
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[[Category: Zhuang Y]]

Revision as of 07:36, 9 November 2022

DAMGO-bound mu-opioid receptor-Gi complex

PDB ID 8efq

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OCA

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