8eg4
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==[iU:Ag+:iU] Metal-mediated DNA base pair in a self-assembling rhombohedral lattice== | |
| + | <StructureSection load='8eg4' size='340' side='right'caption='[[8eg4]], [[Resolution|resolution]] 4.18Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8eg4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EG4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene>, <scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eg4 OCA], [https://pdbe.org/8eg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eg4 RCSB], [https://www.ebi.ac.uk/pdbsum/8eg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eg4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | DNA double helices containing metal-mediated DNA (mmDNA) base pairs have been constructed from Ag(+) and Hg(2+) ions between pyrimidine:pyrimidine pairs with the promise of nanoelectronics. Rational design of mmDNA nanomaterials has been impractical without a complete lexical and structural description. Here, we explore the programmability of structural DNA nanotechnology toward its founding mission of self-assembling a diffraction platform for biomolecular structure determination. We employed the tensegrity triangle to build a comprehensive structural library of mmDNA pairs via X-ray diffraction and elucidated generalized design rules for mmDNA construction. We uncovered two binding modes: N3-dominant, centrosymmetric pairs and major groove binders driven by 5-position ring modifications. Energy gap calculations showed additional levels in the lowest unoccupied molecular orbitals (LUMO) of mmDNA structures, rendering them attractive molecular electronic candidates. This article is protected by copyright. All rights reserved. | ||
| - | + | Metal-Mediated DNA Nanotechnology in 3D: Structural Library by Templated Diffraction.,Vecchioni S, Lu B, Livernois W, Ohayon YP, Yoder JB, Yang CF, Woloszyn K, Bernfeld W, Anantram MP, Canary JW, Hendrickson WA, Rothschild LJ, Mao C, Wind SJ, Seeman NC, Sha R Adv Mater. 2023 Mar 20:e2201938. doi: 10.1002/adma.202201938. PMID:36939292<ref>PMID:36939292</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8eg4" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Sha | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Lu B]] | ||
| + | [[Category: Ohayon YP]] | ||
| + | [[Category: Seeman NC]] | ||
| + | [[Category: Sha R]] | ||
| + | [[Category: Vecchioni S]] | ||
Revision as of 06:29, 7 April 2023
[iU:Ag+:iU] Metal-mediated DNA base pair in a self-assembling rhombohedral lattice
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