8gt7

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'''Unreleased structure'''
 
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The entry 8gt7 is ON HOLD until Paper Publication
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==Structure of falcipain and human Stefin A mutant complex==
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<StructureSection load='8gt7' size='340' side='right'caption='[[8gt7]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
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Authors: Chakraborty, S., Biswas, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8gt7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GT7 FirstGlance]. <br>
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Description: Structure of falcipain and human Stefin A mutant complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.28&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PE8:3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL'>PE8</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Chakraborty, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gt7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gt7 OCA], [https://pdbe.org/8gt7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gt7 RCSB], [https://www.ebi.ac.uk/pdbsum/8gt7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gt7 ProSAT]</span></td></tr>
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[[Category: Biswas, S]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FPC2A_PLAF7 FPC2A_PLAF7] Cysteine protease which cleaves native host hemoglobin and globin in the food vacuole during the asexual blood stage (PubMed:10887194, PubMed:15070727, PubMed:15964982, PubMed:19357776, PubMed:25791019, PubMed:16777845). The binding to host hemoglobin is pH-sensitive and only occurs at acidic pH (PubMed:16777845). Cleaves ankyrin and protein 4.1, two components of host erythrocyte membrane cytoskeleton required for the stability of the erythrocyte membrane, and thus may be involved in parasite release (PubMed:11463472). Preferentially cleaves substrates which have an arginine or lysine at the P1 position and a leucine or phenylalanine at the P2 position (PubMed:10887194, PubMed:19357776).<ref>PMID:10887194</ref> <ref>PMID:11463472</ref> <ref>PMID:15070727</ref> <ref>PMID:15964982</ref> <ref>PMID:16777845</ref> <ref>PMID:19357776</ref> <ref>PMID:25791019</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Biswas S]]
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[[Category: Chakraborty S]]

Revision as of 11:15, 14 March 2024

Structure of falcipain and human Stefin A mutant complex

PDB ID 8gt7

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