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1iqa

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{{STRUCTURE_1iqa| PDB=1iqa | SCENE= }}
{{STRUCTURE_1iqa| PDB=1iqa | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MOUSE RANK LIGAND'''
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===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MOUSE RANK LIGAND===
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==Overview==
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Bone remodeling involves the resorption of bone by osteoclasts and the synthesis of bone matrix by osteoblasts. Receptor activator of NF-kappa B ligand (RANKL, also known as ODF and OPGL), a member of the tumor necrosis factor (TNF) family, triggers osteoclastogenesis by forming a complex with its receptor, RANK. We have determined the crystal structure of the extracellular domain of mouse RANKL at 2.2-A resolution. The structure reveals that the RANKL extracellular domain is trimeric, which was also shown by analytical ultracentrifugation, and each subunit has a beta-strand jellyroll topology like the other members of the TNF family. A comparison of RANKL with TNF beta and TNF-related apoptosis-inducing ligand (TRAIL), whose structures were determined to be in the complex form with their respective receptor, reveals conserved and specific features of RANKL in the TNF superfamily and suggests the presence of key residues of RANKL for receptor binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_11733492}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11733492 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11733492}}
==About this Structure==
==About this Structure==
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[[Category: Rankl]]
[[Category: Rankl]]
[[Category: Tnf]]
[[Category: Tnf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:16:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:48:14 2008''

Revision as of 10:48, 1 July 2008

Image:1iqa.png

Template:STRUCTURE 1iqa

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MOUSE RANK LIGAND

Template:ABSTRACT PUBMED 11733492

About this Structure

1IQA is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution., Ito S, Wakabayashi K, Ubukata O, Hayashi S, Okada F, Hata T, J Biol Chem. 2002 Feb 22;277(8):6631-6. Epub 2001 Nov 30. PMID:11733492

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