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1iqd

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[[Image:1iqd.jpg|left|200px]]
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{{STRUCTURE_1iqd| PDB=1iqd | SCENE= }}
{{STRUCTURE_1iqd| PDB=1iqd | SCENE= }}
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'''Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab.'''
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===Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab.===
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==Overview==
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The development of an immune response to infused factor VIII is a complication affecting many patients with hemophilia A. Inhibitor antibodies bind to antigenic determinants on the factor VIII molecule and block its procoagulant activity. A patient-derived inhibitory immunoglobulin G4kappa antibody (BO2C11) produced by an immortalized memory B-lymphocyte cell line interferes with the binding of factor VIII to phospholipid surfaces and to von Willebrand factor. The structure of a Fab fragment derived from this antibody complexed with the factor VIII C2 domain was determined at 2.0 A resolution. The Fab interacts with solvent-exposed basic and hydrophobic side chains that form a membrane-association surface of factor VIII. This atomic resolution structure suggests a variety of amino acid substitutions in the C2 domain of factor VIII that might prevent the binding of anti-C2 inhibitor antibodies without significantly compromising the procoagulant functions of factor VIII.
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(as it appears on PubMed at http://www.pubmed.gov), where 11418455 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11418455}}
==About this Structure==
==About this Structure==
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[[Category: Factor viii]]
[[Category: Factor viii]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:16:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:48:29 2008''

Revision as of 10:48, 1 July 2008

Image:1iqd.png

Template:STRUCTURE 1iqd

Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab.

Template:ABSTRACT PUBMED 11418455

About this Structure

1IQD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII., Spiegel PC Jr, Jacquemin M, Saint-Remy JM, Stoddard BL, Pratt KP, Blood. 2001 Jul 1;98(1):13-9. PMID:11418455

Page seeded by OCA on Tue Jul 1 13:48:29 2008

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