1ir9

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[[Image:1ir9.jpg|left|200px]]
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{{STRUCTURE_1ir9| PDB=1ir9 | SCENE= }}
{{STRUCTURE_1ir9| PDB=1ir9 | SCENE= }}
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'''IM mutant of lysozyme'''
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===IM mutant of lysozyme===
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==Overview==
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X-ray structure determination of proteins by using the multiple-wavelength anomalous dispersion method targeting selenomethionine is now widely employed. Isoleucine was examined for the second choice of the substitution of methionine next to leucine. We performed a systematic mutational study of the substitutions of methionine for isoleucine. All mutated lysozymes were less stable than the wild-type by about 1 kcal/mol and it is suggested that this instability was caused by the change in residual hydrophobicity from isoleucine to methionine. The X-ray structures of all mutant lysozymes were very similar to that of the wild-type. In addition, both the accessible surface areas and the conformation of the side chain of methionine in all mutant lysozymes were similar to those of the side chain at the respective isoleucine in the wild-type. Therefore, it is suggested that the mutation from isoleucine to methionine in a protein can be considered as a "safe" substitution.
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(as it appears on PubMed at http://www.pubmed.gov), where 11477222 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11477222}}
==About this Structure==
==About this Structure==
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[[Category: Egg white]]
[[Category: Egg white]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:18:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:51:30 2008''

Revision as of 10:51, 1 July 2008

Image:1ir9.png

Template:STRUCTURE 1ir9

IM mutant of lysozyme

Template:ABSTRACT PUBMED 11477222

About this Structure

1IR9 is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Tolerance of point substitution of methionine for isoleucine in hen egg white lysozyme., Ohmura T, Ueda T, Hashimoto Y, Imoto T, Protein Eng. 2001 Jun;14(6):421-5. PMID:11477222

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