8bba

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:03, 25 October 2023) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8bba is ON HOLD until Paper Publication
+
==IPNS H270N variant in complex with Fe and ACV under anaerobic conditions==
-
 
+
<StructureSection load='8bba' size='340' side='right'caption='[[8bba]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-
Authors: Rabe, P., Schofield, C.J.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8bba]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_nidulans_FGSC_A4 Aspergillus nidulans FGSC A4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BBA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BBA FirstGlance]. <br>
-
Description: IPNS H270N variant in complex with Fe and ACV under anaerobic conditions
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACV:L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE'>ACV</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
[[Category: Rabe, P]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bba OCA], [https://pdbe.org/8bba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bba RCSB], [https://www.ebi.ac.uk/pdbsum/8bba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bba ProSAT]</span></td></tr>
-
[[Category: Schofield, C.J]]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IPNA_EMENI IPNA_EMENI] Isopenicillin N synthase; part of the gene cluster that mediates the biosynthesis of penicillin, the world's most important antibiotic (PubMed:3319778, PubMed:11755401). IpnA catalyzes the cyclization of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) to form isopenicillin N (IPN) that contains the beta-lactam nucleus (PubMed:3319778, PubMed:11755401, PubMed:28703303). The penicillin biosynthesis occurs via 3 enzymatic steps, the first corresponding to the production of the tripeptide N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (LLD-ACV or ACV) by the NRPS acvA. The tripeptide ACV is then cyclized to isopenicillin N (IPN) by the isopenicillin N synthase ipnA that forms the beta-lactam nucleus. Finally, the alpha-aminoadipyl side chain is exchanged for phenylacetic acid by the isopenicillin N acyltransferase penDE to yield penicillin in the peroxisomal matrix (By similarity).[UniProtKB:P08703]<ref>PMID:11755401</ref> <ref>PMID:28703303</ref> <ref>PMID:3319778</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Aspergillus nidulans FGSC A4]]
 +
[[Category: Large Structures]]
 +
[[Category: Rabe P]]
 +
[[Category: Schofield CJ]]

Current revision

IPNS H270N variant in complex with Fe and ACV under anaerobic conditions

PDB ID 8bba

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8bba"
Personal tools