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8gva

From Proteopedia

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Current revision (20:34, 12 April 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8gva is ON HOLD until Paper Publication
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==The intermediate structure of hAE2 in basic pH==
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<StructureSection load='8gva' size='340' side='right'caption='[[8gva]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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Authors: Zhang, Q., Jian, L., Yao, D., Rao, B., Hu, K., Xia, Y., Cao, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8gva]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GVA FirstGlance]. <br>
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Description: The intermediate structure of hAE2 in basic pH
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gva OCA], [https://pdbe.org/8gva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gva RCSB], [https://www.ebi.ac.uk/pdbsum/8gva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gva ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Cao, Y]]
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== Function ==
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[[Category: Rao, B]]
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[https://www.uniprot.org/uniprot/B3A2_HUMAN B3A2_HUMAN] Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15184086, PubMed:34668226). Plays an important role in osteoclast differentiation and function (PubMed:34668226). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (By similarity). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (By similarity).[UniProtKB:P13808]<ref>PMID:15184086</ref> <ref>PMID:34668226</ref>
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[[Category: Hu, K]]
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== References ==
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[[Category: Jian, L]]
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<references/>
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[[Category: Yao, D]]
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__TOC__
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[[Category: Xia, Y]]
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</StructureSection>
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[[Category: Zhang, Q]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cao Y]]
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[[Category: Hu K]]
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[[Category: Jian L]]
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[[Category: Rao B]]
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[[Category: Xia Y]]
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[[Category: Yao D]]
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[[Category: Zhang Q]]

Current revision

The intermediate structure of hAE2 in basic pH

PDB ID 8gva

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OCA

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