1is7

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[[Image:1is7.gif|left|200px]]
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{{STRUCTURE_1is7| PDB=1is7 | SCENE= }}
{{STRUCTURE_1is7| PDB=1is7 | SCENE= }}
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'''Crystal structure of rat GTPCHI/GFRP stimulatory complex'''
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===Crystal structure of rat GTPCHI/GFRP stimulatory complex===
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==Overview==
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In the presence of phenylalanine, GTP cyclohydrolase I feedback regulatory protein (GFRP) forms a stimulatory 360-kDa complex with GTP cyclohydrolase I (GTPCHI), which is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. The crystal structure of the stimulatory complex reveals that the GTPCHI decamer is sandwiched by two GFRP homopentamers. Each GFRP pentamer forms a symmetrical five-membered ring similar to beta-propeller. Five phenylalanine molecules are buried inside each interface between GFRP and GTPCHI, thus enhancing the binding of these proteins. The complex structure suggests that phenylalanine-induced GTPCHI x GFRP complex formation enhances GTPCHI activity by locking the enzyme in the active state.
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(as it appears on PubMed at http://www.pubmed.gov), where 11818540 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11818540}}
==About this Structure==
==About this Structure==
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[[Category: Okada, K.]]
[[Category: Okada, K.]]
[[Category: Enzyme-regulatory protein complex]]
[[Category: Enzyme-regulatory protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:21:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:54:44 2008''

Revision as of 10:54, 1 July 2008

Image:1is7.png

Template:STRUCTURE 1is7

Crystal structure of rat GTPCHI/GFRP stimulatory complex

Template:ABSTRACT PUBMED 11818540

About this Structure

1IS7 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP., Maita N, Okada K, Hatakeyama K, Hakoshima T, Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1212-7. Epub 2002 Jan 29. PMID:11818540

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