4gmk
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4gmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ligilactobacillus_salivarius_UCC118 Ligilactobacillus salivarius UCC118]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMK FirstGlance]. <br> | <table><tr><td colspan='2'>[[4gmk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ligilactobacillus_salivarius_UCC118 Ligilactobacillus salivarius UCC118]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GMK FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmk OCA], [https://pdbe.org/4gmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmk RCSB], [https://www.ebi.ac.uk/pdbsum/4gmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gmk OCA], [https://pdbe.org/4gmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gmk RCSB], [https://www.ebi.ac.uk/pdbsum/4gmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gmk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/Q1WR87_LIGS1 Q1WR87_LIGS1] Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.[HAMAP-Rule:MF_00170] | [https://www.uniprot.org/uniprot/Q1WR87_LIGS1 Q1WR87_LIGS1] Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.[HAMAP-Rule:MF_00170] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The structure of ribose 5-phosphate isomerase from the probiotic bacterium Lactobacillus salivarius UCC188 has been determined at 1.72 A resolution. The structure was solved by molecular replacement, which identified the functional homodimer in the asymmetric unit. Despite only showing 57% sequence identity to its closest homologue, the structure adopted the typical alpha and beta D-ribose 5-phosphate isomerase fold. Comparison to other related structures revealed high homology in the active site, allowing a model of the substrate-bound protein to be proposed. The determination of the structure was expedited by the use of in situ crystallization-plate screening on beamline I04-1 at Diamond Light Source to identify well diffracting protein crystals prior to routine cryocrystallography. | ||
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| - | Structure of ribose 5-phosphate isomerase from the probiotic bacterium Lactobacillus salivarius UCC118.,Lobley CM, Aller P, Douangamath A, Reddivari Y, Bumann M, Bird LE, Nettleship JE, Brandao-Neto J, Owens RJ, O'Toole PW, Walsh MA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1427-33., doi: 10.1107/S174430911204273X. Epub 2012 Nov 14. PMID:23192019<ref>PMID:23192019</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 4gmk" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Ribose-5-phosphate isomerase 3D structures|Ribose-5-phosphate isomerase 3D structures]] | *[[Ribose-5-phosphate isomerase 3D structures|Ribose-5-phosphate isomerase 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal Structure of Ribose 5-Phosphate Isomerase from the Probiotic Bacterium Lactobacillus salivarius UCC118
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