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1itm

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[[Image:1itm.gif|left|200px]]
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{{Seed}}
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[[Image:1itm.png|left|200px]]
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{{STRUCTURE_1itm| PDB=1itm | SCENE= }}
{{STRUCTURE_1itm| PDB=1itm | SCENE= }}
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'''ANALYSIS OF THE SOLUTION STRUCTURE OF HUMAN INTERLEUKIN 4 DETERMINED BY HETERONUCLEAR THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE TECHNIQUES'''
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===ANALYSIS OF THE SOLUTION STRUCTURE OF HUMAN INTERLEUKIN 4 DETERMINED BY HETERONUCLEAR THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE TECHNIQUES===
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==Overview==
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Human interleukin-4 (IL-4) is a member of the family of haemopoietic cytokines that modulate cell proliferation and differentiation within the immune system. It has a four-helix-bundle structure, and possesses a high degree of mobility in certain regions, notably in the two long loops running the length of the bundle in its up-up-down-down topology. Information from a variety of three-dimensional heteronuclear NMR experiments, including chemical shifts, coupling constants and NOE data, is analysed in terms of the solution structure of IL-4. In addition, structure calculations with and without specific restraints such as hydrogen bond location or torsion angle restrictions are compared in the light of the dynamic behaviour of the polypeptide chain. Particular emphasis is placed on defining the lengths and positions of secondary structure elements, and on the likely structural preferences within the less well ordered loop regions. The overall topology of IL-4 is compared with those defined in recent structure determinations of related proteins. This analysis is combined with recent mutagenesis data to propose a possible mode of interaction of IL-4 with its receptor.
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The line below this paragraph, {{ABSTRACT_PUBMED_8145254}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8145254 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8145254}}
==About this Structure==
==About this Structure==
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1ITM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITM OCA].
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1ITM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITM OCA].
==Reference==
==Reference==
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[[Category: Smith, R A.G.]]
[[Category: Smith, R A.G.]]
[[Category: Cytokine]]
[[Category: Cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:23:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:58:46 2008''

Revision as of 10:58, 1 July 2008

Image:1itm.png

Template:STRUCTURE 1itm

ANALYSIS OF THE SOLUTION STRUCTURE OF HUMAN INTERLEUKIN 4 DETERMINED BY HETERONUCLEAR THREE-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE TECHNIQUES

Template:ABSTRACT PUBMED 8145254

About this Structure

1ITM is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Analysis of the solution structure of human interleukin-4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques., Redfield C, Smith LJ, Boyd J, Lawrence GM, Edwards RG, Gershater CJ, Smith RA, Dobson CM, J Mol Biol. 1994 Apr 22;238(1):23-41. PMID:8145254

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