Sandbox Reserved 1737

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==Structure==
==Structure==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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Primary Structure: ~461 amino acids
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Secondary Structure: 12 alpha helicies, 12 beta strands
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Tertiary Structure: N-Terminal Regulatory Domain, C-Terminal Catalytic Domain
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Quaternary Structure: Forms a homodimer
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== Function ==
== Function ==
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Glucose binds to hexokinase, which is then attacked by ATP. The terminal phosphate group on the ATP binds to the glucose, creating two products: glucose-6-phosphate, and ADP. Hexokinase serves as a catalyst for this reaction.
== Disease ==
== Disease ==

Revision as of 02:11, 28 October 2022

This Sandbox is Reserved from August 30, 2022 through May 31, 2023 for use in the course Biochemistry I taught by Kimberly Lane at the Radford University, Radford, VA, USA. This reservation includes Sandbox Reserved 1730 through Sandbox Reserved 1749.
To get started:
  • Click the edit this page tab at the top. Click on Show preview and then Save the page after each step, then edit it again.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Structure

Caption for this structure

Drag the structure with the mouse to rotate

References

1. D. J. Roberts, S. Miyamoto. Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291497/ (Accessed 10/21/2022).

2. Anne M. Mulichuk, John E. Wilson, Kaillathe Padmanabhan, Michael Garavito. The structure of mammalian hexokinase-1. https://www.nature.com/articles/nsb0798_555. (Accessed 10/21/2022).

3. Valerie P. Tan, Shigeki Miyamoto. HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection. https://pubmed.ncbi.nlm.nih.gov/26075878/. (Accessed 10/21/2022).

4. M. Magnani, M. Bianchi, A. Casabianca, V. Stocchi, A. Daniele, F. Altruda, M. Ferrone, L. Silengo. A recombinant human 'mini'-hexokinase is catalytically active and regulated by hexose 6-phosphates. https://pubmed.ncbi.nlm.nih.gov/1637300/. (Accessed 10/21/2022).

5. A. E. Aleshin, C. Zeng, G. P. Bourenkov, H. D. Bartunik, H. J. Fromm, R. B. Honzatko. The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate. https://pubmed.ncbi.nlm.nih.gov/9493266/. (Accessed 10/21/2022).

6. Richard Southworth, Katherine A. B. Davey, Alice Warley, Pamela B. Garlick. A reevaluation of the roles of hexokinase I and II in the heart. https://journals.physiology.org/doi/full/10.1152/ajpheart.00664.2006. (Accessed 10/21/2022)

7. Èric Claeyssen, Jean Rivoal. Isozymes of plant hexokinase: Occurrence, properties and functions. https://www.sciencedirect.com/science/article/abs/pii/S0031942206007606. (Accessed 10/21/2022)


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