8gxq

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Current revision (11:59, 30 October 2024) (edit) (undo)
 
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<StructureSection load='8gxq' size='340' side='right'caption='[[8gxq]], [[Resolution|resolution]] 5.04&Aring;' scene=''>
<StructureSection load='8gxq' size='340' side='right'caption='[[8gxq]], [[Resolution|resolution]] 5.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[8gxq]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GXQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[8gxq]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GXQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.04&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gxq OCA], [https://pdbe.org/8gxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gxq RCSB], [https://www.ebi.ac.uk/pdbsum/8gxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gxq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gxq OCA], [https://pdbe.org/8gxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gxq RCSB], [https://www.ebi.ac.uk/pdbsum/8gxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gxq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[https://www.uniprot.org/uniprot/A0A4X1ULF2_PIG A0A4X1ULF2_PIG] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.[PIRNR:PIRNR000779]
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[https://www.uniprot.org/uniprot/MED6_HUMAN MED6_HUMAN] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:16595664</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Sus scrofa]]
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[[Category: Synthetic construct]]
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[[Category: Xenopus laevis]]
[[Category: Chen X]]
[[Category: Chen X]]
[[Category: Li J]]
[[Category: Li J]]

Current revision

PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state

PDB ID 8gxq

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