1ivo

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[[Image:1ivo.gif|left|200px]]
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{{STRUCTURE_1ivo| PDB=1ivo | SCENE= }}
{{STRUCTURE_1ivo| PDB=1ivo | SCENE= }}
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'''Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.'''
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===Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.===
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==Overview==
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Epidermal growth factor (EGF) regulates cell proliferation and differentiation by binding to the EGF receptor (EGFR) extracellular region, comprising domains I-IV, with the resultant dimerization of the receptor tyrosine kinase. In this study, the crystal structure of a 2:2 complex of human EGF and the EGFR extracellular region has been determined at 3.3 A resolution. EGFR domains I-III are arranged in a C shape, and EGF is docked between domains I and III. The 1:1 EGF*EGFR complex dimerizes through a direct receptor*receptor interaction, in which a protruding beta-hairpin arm of each domain II holds the body of the other. The unique "receptor-mediated dimerization" was verified by EGFR mutagenesis.
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(as it appears on PubMed at http://www.pubmed.gov), where 12297050 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12297050}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:28:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:04:56 2008''

Revision as of 11:04, 1 July 2008

Image:1ivo.png

Template:STRUCTURE 1ivo

Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.

Template:ABSTRACT PUBMED 12297050

About this Structure

1IVO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains., Ogiso H, Ishitani R, Nureki O, Fukai S, Yamanaka M, Kim JH, Saito K, Sakamoto A, Inoue M, Shirouzu M, Yokoyama S, Cell. 2002 Sep 20;110(6):775-87. PMID:12297050

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