1iwg

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[[Image:1iwg.jpg|left|200px]]
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[[Image:1iwg.png|left|200px]]
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==Overview==
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{{ABSTRACT_12374972}}
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AcrB is a major multidrug exporter in Escherichia coli. It cooperates with a membrane fusion protein, AcrA, and an outer membrane channel, TolC. We have determined the crystal structure of AcrB at 3.5 A resolution. Three AcrB protomers are organized as a homotrimer in the shape of a jellyfish. Each protomer is composed of a transmembrane region 50 A thick and a 70 A protruding headpiece. The top of the headpiece opens like a funnel, where TolC might directly dock into AcrB. A pore formed by three alpha-helices connects the funnel with a central cavity located at the bottom of the headpiece. The cavity has three vestibules at the side of the headpiece which lead into the periplasm. In the transmembrane region, each protomer has twelve transmembrane alpha-helices. The structure implies that substrates translocated from the cell interior through the transmembrane region and from the periplasm through the vestibules are collected in the central cavity and then actively transported through the pore into the TolC tunnel.
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==About this Structure==
==About this Structure==
1IWG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IWG OCA].
1IWG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IWG OCA].
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==Reference==
 
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Crystal structure of bacterial multidrug efflux transporter AcrB., Murakami S, Nakashima R, Yamashita E, Yamaguchi A, Nature. 2002 Oct 10;419(6907):587-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12374972 12374972]
 
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Multidrug efflux]]
[[Category: Multidrug efflux]]
[[Category: Transporter]]
[[Category: Transporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:30:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:34:03 2008''

Revision as of 14:34, 26 June 2008

Image:1iwg.png

Template:STRUCTURE 1iwg

Crystal structure of Bacterial Multidrug Efflux transporter AcrB


Template:ABSTRACT 12374972

About this Structure

1IWG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:34:03 2008

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