1iwm

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{{STRUCTURE_1iwm| PDB=1iwm | SCENE= }}
{{STRUCTURE_1iwm| PDB=1iwm | SCENE= }}
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'''Crystal Structure of the Outer Membrane Lipoprotein Receptor, LolB'''
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===Crystal Structure of the Outer Membrane Lipoprotein Receptor, LolB===
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==Overview==
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Lipoproteins having a lipid-modified cysteine at the N-terminus are localized on either the inner or the outer membrane of Escherichia coli depending on the residue at position 2. Five Lol proteins involved in the sorting and membrane localization of lipoprotein are highly conserved in Gram-negative bacteria. We determined the crystal structures of a periplasmic chaperone, LolA, and an outer membrane lipoprotein receptor, LolB. Despite their dissimilar amino acid sequences, the structures of LolA and LolB are strikingly similar to each other. Both have a hydrophobic cavity consisting of an unclosed beta barrel and an alpha-helical lid. The cavity represents a possible binding site for the lipid moiety of lipoproteins. Detailed structural differences between the two proteins provide significant insights into the molecular mechanisms underlying the energy-independent transfer of lipoproteins from LolA to LolB and from LolB to the outer membrane. Furthermore, the structures of both LolA and LolB determined from different crystal forms revealed the distinct structural dynamics regarding the association and dissociation of lipoproteins. The results are discussed in the context of the current model for the lipoprotein transfer from the inner to the outer membrane through a hydrophilic environment.
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{{ABSTRACT_PUBMED_12839983}}
==About this Structure==
==About this Structure==
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[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
[[Category: Unclosed beta barrel]]
[[Category: Unclosed beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:30:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:08:01 2008''

Revision as of 11:08, 1 July 2008

Image:1iwm.png

Template:STRUCTURE 1iwm

Crystal Structure of the Outer Membrane Lipoprotein Receptor, LolB

Template:ABSTRACT PUBMED 12839983

About this Structure

1IWM is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structures of bacterial lipoprotein localization factors, LolA and LolB., Takeda K, Miyatake H, Yokota N, Matsuyama S, Tokuda H, Miki K, EMBO J. 2003 Jul 1;22(13):3199-209. PMID:12839983

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