1iwq

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[[Image:1iwq.gif|left|200px]]
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{{STRUCTURE_1iwq| PDB=1iwq | SCENE= }}
{{STRUCTURE_1iwq| PDB=1iwq | SCENE= }}
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'''Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin'''
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===Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin===
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==Overview==
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The calmodulin-binding domain of myristoylated alanine-rich C kinase substrate (MARCKS), which interacts with various targets including calmodulin, actin and membrane lipids, has been suggested to function as a crosstalk point among several signal transduction pathways. We present here the crystal structure at 2 A resolution of a peptide consisting of the MARCKS calmodulin (CaM)-binding domain in complex with Ca2+-CaM. The domain assumes a flexible conformation, and the hydrophobic pocket of the calmodulin N-lobe, which is a common CaM-binding site observed in previously resolved Ca2+-CaM-target peptide complexes, is not involved in the interaction. The present structure presents a novel target-recognition mode of calmodulin and provides insight into the structural basis of the flexible interaction module of MARCKS.
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(as it appears on PubMed at http://www.pubmed.gov), where 12577052 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12577052}}
==About this Structure==
==About this Structure==
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[[Category: Rsgi]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:31:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:08:18 2008''

Revision as of 11:08, 1 July 2008

Image:1iwq.png

Template:STRUCTURE 1iwq

Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin

Template:ABSTRACT PUBMED 12577052

About this Structure

1IWQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin., Yamauchi E, Nakatsu T, Matsubara M, Kato H, Taniguchi H, Nat Struct Biol. 2003 Mar;10(3):226-31. PMID:12577052

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