8egs
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Tail knob structure of Staphylococcus phage Andhra== | |
| + | <StructureSection load='8egs' size='340' side='right'caption='[[8egs]], [[Resolution|resolution]] 3.92Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8egs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rakietenvirinae Rakietenvirinae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EGS FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8egs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8egs OCA], [https://pdbe.org/8egs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8egs RCSB], [https://www.ebi.ac.uk/pdbsum/8egs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8egs ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1S6L1I1_9CAUD A0A1S6L1I1_9CAUD] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Staphylococcus epidermidis is an opportunistic pathogen of the human skin, often associated with infections of implanted medical devices. Staphylococcal picoviruses are a group of strictly lytic, short-tailed bacteriophages with compact genomes that are attractive candidates for therapeutic use. Here, we report the structure of the complete virion of S. epidermidis-infecting phage Andhra, determined using high-resolution cryo-electron microscopy, allowing atomic modeling of 11 capsid and tail proteins. The capsid is a T = 4 icosahedron containing a unique stabilizing capsid lining protein. The tail includes 12 trimers of a unique receptor binding protein (RBP), a lytic protein that also serves to anchor the RBPs to the tail stem, and a hexameric tail knob that acts as a gatekeeper for DNA ejection. Using structure prediction with AlphaFold, we identified the two proteins that comprise the tail tip heterooctamer. Our findings elucidate critical features for virion assembly, host recognition, and penetration. | ||
| - | + | Structure and host specificity of Staphylococcus epidermidis bacteriophage Andhra.,Hawkins NC, Kizziah JL, Hatoum-Aslan A, Dokland T Sci Adv. 2022 Dec 2;8(48):eade0459. doi: 10.1126/sciadv.ade0459. Epub 2022 Nov , 30. PMID:36449623<ref>PMID:36449623</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8egs" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rakietenvirinae]] | ||
| + | [[Category: Dokland T]] | ||
| + | [[Category: Hawkins NC]] | ||
| + | [[Category: Kizziah JL]] | ||
Revision as of 10:11, 14 December 2022
Tail knob structure of Staphylococcus phage Andhra
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