1hdm
From Proteopedia
(New page: 200px<br /> <applet load="1hdm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hdm, resolution 2.5Å" /> '''HISTOCOMPATIBILITY A...) |
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caption="1hdm, resolution 2.5Å" /> | caption="1hdm, resolution 2.5Å" /> | ||
'''HISTOCOMPATIBILITY ANTIGEN HLA-DM'''<br /> | '''HISTOCOMPATIBILITY ANTIGEN HLA-DM'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HDM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1HDM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HDM OCA]. |
==Reference== | ==Reference== | ||
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[[Category: histocompatibility protein]] | [[Category: histocompatibility protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:56:10 2008'' |
Revision as of 13:56, 15 February 2008
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HISTOCOMPATIBILITY ANTIGEN HLA-DM
Contents |
Overview
The three-dimensional structure of the soluble ecto-domain of HLA-DM has, been determined to 2.5 A resolution by X-ray crystallography. HLA-DM has, both peptide exchange activity and acts as a chaperone to peptide-free, class II MHC molecules. As predicted, the structure is similar to that of, classical class II MHC molecules except that the peptide-binding site is, altered to an almost fully closed groove. An unusual cavity is found at, the center of the region that binds peptides in class II MHC molecules, and a tryptophanrich lateral surface is identified that is a candidate, both for binding to HLA-DR, to effect catalysis, and to HLA-DO, an, inhibitor.
Disease
Known diseases associated with this structure: Branchiootorenal syndrome 2 OMIM:[600963], Glioblastoma multiforme, somatic OMIM:[601969], Medulloblastoma OMIM:[601969]
About this Structure
1HDM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation., Mosyak L, Zaller DM, Wiley DC, Immunity. 1998 Sep;9(3):377-83. PMID:9768757
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