1iyu

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[[Image:1iyu.gif|left|200px]]
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[[Image:1iyu.png|left|200px]]
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{{STRUCTURE_1iyu| PDB=1iyu | SCENE= }}
{{STRUCTURE_1iyu| PDB=1iyu | SCENE= }}
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'''LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE'''
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===LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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The three-dimensional structure of the N-terminal lipoyl domain of the acetyltransferase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii has been determined using heteronuclear multidimensional NMR spectroscopy and dynamical simulated annealing. The structure is compared with the solution structure of the lipoyl domain of the A. vinelandii 2-oxoglutarate dehydrogenase complex. The overall fold of the two structures, described as a beta-barrel-sandwich hybrid, is very similar. This agrees well with the high similarity of NMR-derived parameters, e.g. chemical shifts, between the two lipoyl domains. The main structural differences between the two lipoyl domains occur in a solvent-exposed loop close in space to the lipoylation site. Despite their high structural similarity, these lipoyl domains show a high preference for being reductively acylated by their parent 2-oxo acid dehydrogenase. Potential residues of the lipoyl domain involved in this process of molecular recognition are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 9119000 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9119000}}
==About this Structure==
==About this Structure==
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1IYU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IYU OCA].
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1IYU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IYU OCA].
==Reference==
==Reference==
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[[Category: Lipoyl]]
[[Category: Lipoyl]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:35:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:14:29 2008''

Revision as of 11:14, 1 July 2008

Image:1iyu.png

Template:STRUCTURE 1iyu

LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9119000

About this Structure

1IYU is a Single protein structure of sequence from Azotobacter vinelandii. Full experimental information is available from OCA.

Reference

Three-dimensional structure in solution of the N-terminal lipoyl domain of the pyruvate dehydrogenase complex from Azotobacter vinelandii., Berg A, Vervoort J, de Kok A, Eur J Biochem. 1997 Mar 1;244(2):352-60. PMID:9119000

Page seeded by OCA on Tue Jul 1 14:14:29 2008

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