1iz2

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[[Image:1iz2.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1iz2| PDB=1iz2 | SCENE= }}
{{STRUCTURE_1iz2| PDB=1iz2 | SCENE= }}
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'''Interactions causing the kinetic trap in serpin protein folding'''
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===Interactions causing the kinetic trap in serpin protein folding===
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==Overview==
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Conformational transition is fundamental to the mechanism of functional regulation in proteins, and serpins (serine protease inhibitors) can provide insight into this process. Serpins are metastable in their native forms, and they ordinarily undergo conformational transition to a stable state only when they form a tight complex with target proteases. The metastable native form is thus considered to be a kinetically trapped folding intermediate. We sought to understand the nature of the serpin kinetic trap as a step toward discovering how conformational transition is regulated. We found that mutations of the B/C beta-barrel of native alpha(1)-antitrypsin, a prototypical serpin, allowed conversion of the molecule into a more stable state. A 2.2 A resolution crystal structure of the stable form (PDB code, ) showed that the reactive site loop is inserted into an A beta-sheet, as in the latent plasminogen activator inhibitor-1. Mutational analyses suggest strongly that interactions not found in the final stable form cause the kinetic trap in serpin protein folding.
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The line below this paragraph, {{ABSTRACT_PUBMED_12244055}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12244055 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12244055}}
==About this Structure==
==About this Structure==
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[[Category: Folding]]
[[Category: Folding]]
[[Category: Serpin]]
[[Category: Serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:36:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:15:09 2008''

Revision as of 11:15, 1 July 2008

Image:1iz2.png

Template:STRUCTURE 1iz2

Interactions causing the kinetic trap in serpin protein folding

Template:ABSTRACT PUBMED 12244055

About this Structure

1IZ2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Interactions causing the kinetic trap in serpin protein folding., Im H, Woo MS, Hwang KY, Yu MH, J Biol Chem. 2002 Nov 29;277(48):46347-54. Epub 2002 Sep 18. PMID:12244055

Page seeded by OCA on Tue Jul 1 14:15:09 2008

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