1j07

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{{STRUCTURE_1j07| PDB=1j07 | SCENE= }}
{{STRUCTURE_1j07| PDB=1j07 | SCENE= }}
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'''Crystal structure of the mouse acetylcholinesterase-decidium complex'''
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===Crystal structure of the mouse acetylcholinesterase-decidium complex===
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==Overview==
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The peripheral anionic site on acetylcholinesterase (AChE), located at the active center gorge entry, encompasses overlapping binding sites for allosteric activators and inhibitors; yet, the molecular mechanisms coupling this site to the active center at the gorge base to modulate catalysis remain unclear. The peripheral site has also been proposed to be involved in heterologous protein associations occurring during synaptogenesis or upon neurodegeneration. A novel crystal form of mouse AChE, combined with spectrophotometric analyses of the crystals, enabled us to solve unique structures of AChE with a free peripheral site, and as three complexes with peripheral site inhibitors: the phenylphenanthridinium ligands, decidium and propidium, and the pyrogallol ligand, gallamine, at 2.20-2.35 A resolution. Comparison with structures of AChE complexes with the peptide fasciculin or with organic bifunctional inhibitors unveils new structural determinants contributing to ligand interactions at the peripheral site, and permits a detailed topographic delineation of this site. Hence, these structures provide templates for designing compounds directed to the enzyme surface that modulate specific surface interactions controlling catalytic activity and non-catalytic heterologous protein associations.
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The line below this paragraph, {{ABSTRACT_PUBMED_12505979}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12505979 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12505979}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase fold]]
[[Category: Hydrolase fold]]
[[Category: Serine esterase]]
[[Category: Serine esterase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:38:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:17:46 2008''

Revision as of 11:17, 1 July 2008

Image:1j07.png

Template:STRUCTURE 1j07

Crystal structure of the mouse acetylcholinesterase-decidium complex

Template:ABSTRACT PUBMED 12505979

About this Structure

1J07 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site., Bourne Y, Taylor P, Radic Z, Marchot P, EMBO J. 2003 Jan 2;22(1):1-12. PMID:12505979

Page seeded by OCA on Tue Jul 1 14:17:46 2008

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