4igb
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4igb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_gordonii_str._Challis Streptococcus gordonii str. Challis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IGB FirstGlance]. <br> | <table><tr><td colspan='2'>[[4igb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_gordonii_str._Challis Streptococcus gordonii str. Challis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IGB FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4igb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igb OCA], [https://pdbe.org/4igb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4igb RCSB], [https://www.ebi.ac.uk/pdbsum/4igb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4igb ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4igb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4igb OCA], [https://pdbe.org/4igb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4igb RCSB], [https://www.ebi.ac.uk/pdbsum/4igb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4igb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/A8AW49_STRGC A8AW49_STRGC] | [https://www.uniprot.org/uniprot/A8AW49_STRGC A8AW49_STRGC] | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The commensal Streptococcus gordonii expresses numerous surface adhesins with which it interacts with other microorganisms, host cells and salivary proteins to initiate dental plaque formation. However, this Gram-positive bacterium can also spread to non-oral sites such as the heart valves and cause infective endocarditis. One of its surface adhesins, Sgo0707, is a large protein composed of a non-repetitive N-terminal region followed by several C-terminal repeat domains and a cell wall sorting motif. Here we present the crystal structure of the Sgo0707 N-terminal domains, refined to 2.1 A resolution. The model consists of two domains, N1 and N2. The largest domain, N1, comprises a putative binding cleft with a single cysteine located in its centre and exhibits an unexpected structural similarity to the variable domains of the streptococcal Antigen I/II adhesins. The N2-domain has an IgG-like fold commonly found among Gram-positive surface adhesins. Binding studies performed on S. gordonii wild-type and a Sgo0707 deficient mutant show that the Sgo0707 adhesin is involved in binding to type-1 collagen and to oral keratinocytes. | ||
| - | |||
| - | Structural and Functional Analysis of the N-terminal Domain of the Streptococcus gordonii Adhesin Sgo0707.,Nylander A, Svensater G, Senadheera DB, Cvitkovitch DG, Davies JR, Persson K PLoS One. 2013 May 17;8(5):e63768. doi: 10.1371/journal.pone.0063768. Print 2013. PMID:23691093<ref>PMID:23691093</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 4igb" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of the N-terminal domain of the Streptococcus gordonii adhesin Sgo0707
| |||||||||||
