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1j2f

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{{STRUCTURE_1j2f| PDB=1j2f | SCENE= }}
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'''X-ray crystal structure of IRF-3 and its functional implications'''
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===X-ray crystal structure of IRF-3 and its functional implications===
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==Overview==
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Transcription factor IRF-3 is post-translationally activated by Toll-like receptor (TLR) signaling and has critical roles in the regulation of innate immunity. Here we present the X-ray crystal structure of the C-terminal regulatory domain of IRF-3(175-427) (IRF-3 175C) at a resolution of 2.3 A. IRF-3 175C is structurally similar to the Mad homology domain 2 of the Smad family. Structural and functional analyses reveal phosphorylation-induced IRF-3 dimerization, which generates an extensive acidic pocket responsible for binding with p300/CBP. Although TLR and Smad signaling are evolutionarily independent, our results suggest that IRF-3 originates from Smad and acquires its function downstream of TLR.
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{{ABSTRACT_PUBMED_14555995}}
==About this Structure==
==About this Structure==
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[[Category: Terasawa, H.]]
[[Category: Terasawa, H.]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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Revision as of 11:24, 1 July 2008

Image:1j2f.png

Template:STRUCTURE 1j2f

X-ray crystal structure of IRF-3 and its functional implications

Template:ABSTRACT PUBMED 14555995

About this Structure

1J2F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of IRF-3 and its functional implications., Takahasi K, Suzuki NN, Horiuchi M, Mori M, Suhara W, Okabe Y, Fukuhara Y, Terasawa H, Akira S, Fujita T, Inagaki F, Nat Struct Biol. 2003 Nov;10(11):922-7. Epub 2003 Oct 12. PMID:14555995

Page seeded by OCA on Tue Jul 1 14:23:59 2008

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