8d2x

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'''Unreleased structure'''
 
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The entry 8d2x is ON HOLD until Paper Publication
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==Zebrafish MFSD2A isoform B in inward open ligand 3C conformation==
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<StructureSection load='8d2x' size='340' side='right'caption='[[8d2x]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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Authors: Nguyen, C., Lei, H.T., Lai, L.T.F., Gallentino, M.J., Mu, X., Matthies, D., Gonen, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8d2x]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D2X FirstGlance]. <br>
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Description: Zebrafish MFSD2A isoform B in inward open ligand 3C conformation
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=ZGS:[(2~{R})-2-oxidanyl-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propyl]+(9~{Z},12~{Z},15~{Z})-octadeca-9,12,15-trienoate'>ZGS</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d2x OCA], [https://pdbe.org/8d2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d2x RCSB], [https://www.ebi.ac.uk/pdbsum/8d2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d2x ProSAT]</span></td></tr>
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[[Category: Gonen, T]]
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</table>
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[[Category: Matthies, D]]
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== Function ==
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[[Category: Mu, X]]
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[https://www.uniprot.org/uniprot/NLS1B_DANRE NLS1B_DANRE] Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid.[UniProtKB:Q9DA75]
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[[Category: Lai, L.T.F]]
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__TOC__
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[[Category: Nguyen, C]]
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</StructureSection>
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[[Category: Gallentino, M.J]]
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[[Category: Danio rerio]]
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[[Category: Lei, H.T]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Gallentino MJ]]
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[[Category: Gonen T]]
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[[Category: Lai LTF]]
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[[Category: Lei HT]]
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[[Category: Matthies D]]
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[[Category: Mu X]]
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[[Category: Nguyen C]]

Revision as of 06:53, 10 May 2023

Zebrafish MFSD2A isoform B in inward open ligand 3C conformation

PDB ID 8d2x

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