1j2x

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{{STRUCTURE_1j2x| PDB=1j2x | SCENE= }}
{{STRUCTURE_1j2x| PDB=1j2x | SCENE= }}
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'''Crystal structure of RAP74 C-terminal domain complexed with FCP1 C-terminal peptide'''
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===Crystal structure of RAP74 C-terminal domain complexed with FCP1 C-terminal peptide===
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==Overview==
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After mRNA transcription termination in eukaryotes, the hyperphosphorylated form of RNA polymerase II (pol II0) must be recycled by TFIIF-associating C-terminal domain phosphatase (FCP1), the phosphatase responsible for dephosphorylating the C-terminal domain of the largest polymerase subunit. Transcription factor (TF)-IIF stimulates the activity of FCP1, and the RNA polymerase II-associating protein 74 subunit of TFIIF forms a complex with FCP1 in both human and yeast. Here, we report a cocrystal structure of the winged-helix domain of human RNA polymerase II-associating protein 74 bound to the alpha-helical C terminus of human FCP1 (residues 944-961). These results illustrate the molecular mechanism by which TFIIF efficiently recruits FCP1 to the pol II transcription machinery for recycling of the polymerase.
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(as it appears on PubMed at http://www.pubmed.gov), where 12591941 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12591941}}
==About this Structure==
==About this Structure==
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[[Category: Tfiif]]
[[Category: Tfiif]]
[[Category: Winged-helix domain]]
[[Category: Winged-helix domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:44:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:25:15 2008''

Revision as of 11:25, 1 July 2008

Image:1j2x.png

Template:STRUCTURE 1j2x

Crystal structure of RAP74 C-terminal domain complexed with FCP1 C-terminal peptide

Template:ABSTRACT PUBMED 12591941

About this Structure

1J2X is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF., Kamada K, Roeder RG, Burley SK, Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2296-9. Epub 2003 Feb 18. PMID:12591941

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