1j42

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[[Image:1j42.gif|left|200px]]
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{{STRUCTURE_1j42| PDB=1j42 | SCENE= }}
{{STRUCTURE_1j42| PDB=1j42 | SCENE= }}
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'''Crystal Structure of Human DJ-1'''
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===Crystal Structure of Human DJ-1===
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==Overview==
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Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family, whose members contain a conserved domain. DJ-1 is associated with autosomal recessive early onset parkinsonism and Hsp31 is a molecular chaperone. Structural comparisons between DJ-1, Hsp31, and an Archaea protease, a member of ThiJ/PfpI family, lead to the identification of the chaperone activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the comparisons provide insights into how the functional diversity is realized in proteins that share an evolutionarily conserved domain. On the basis of the chaperone activity the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 12939276 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12939276}}
==About this Structure==
==About this Structure==
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[[Category: Cha, S S.]]
[[Category: Cha, S S.]]
[[Category: Parkinson's disease]]
[[Category: Parkinson's disease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:46:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:28:23 2008''

Revision as of 11:28, 1 July 2008

Image:1j42.png

Template:STRUCTURE 1j42

Crystal Structure of Human DJ-1

Template:ABSTRACT PUBMED 12939276

About this Structure

1J42 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain., Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH, Park C, Kang SO, Suh PG, Lee HS, Cha SS, J Biol Chem. 2003 Nov 7;278(45):44552-9. Epub 2003 Aug 25. PMID:12939276

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