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<StructureSection load='3b5r' size='350' side='right' caption='AR' scene=''> | <StructureSection load='3b5r' size='350' side='right' caption='AR' scene=''> | ||
| - | The androgen receptor (AR) belongs to the steroid hormone group nuclear receptor family with the estrogen, progesterone, glucocorticoid and mineralcorticoid receptor. | ||
| - | AR mediate the actions of testosterone and a more biologically active form, dihydrotestosterone (DHT), which are the male sex hormones required for development of the male reproductive system and secondary sexual characteristics. This receptor is expressed in a diverse range of tissues, because they have significant biological actions in many systems. | ||
| - | == Structure == | ||
<scene name='85/857155/H12_androgen_receptor/1'>H12</scene> | <scene name='85/857155/H12_androgen_receptor/1'>H12</scene> | ||
| - | == Function == | ||
| - | == Structural highlights == | ||
| - | == 3D Structures of androgen receptor == | ||
| - | |||
| - | ==drugs== | ||
<scene name='85/857155/Bicatulamide_in_ar/1'>bicatulamide</scene> | <scene name='85/857155/Bicatulamide_in_ar/1'>bicatulamide</scene> | ||
</StructureSection> | </StructureSection> | ||
Revision as of 12:42, 27 November 2022
The androgen receptor (AR) belongs to the steroid hormone group nuclear receptor family with the estrogen, progesterone, glucocorticoid and mineralcorticoid receptor. AR mediate the actions of testosterone (T) and a more biologically active form, 5α-dihydrotestosterone (DHT), which are the male sex hormones required for development of the male reproductive system and secondary sexual characteristics. This receptor, located on the X chromosome, is expressed in a diverse range of tissues, because they have significant biological actions in many systems [1]. There are other androgens that bind with much less potency than T and DHT such as androstenedione, androstenediol, and dehydroepiandrosterone (DHEA) [2].
Structure
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