This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Glyoxylate cycle
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
The glyoxylate cycle, a variation of the [[tricarboxylic acid cycle]], is an anabolic pathway occurring in plants, bacteria, protists, and fungi. The glyoxylate cycle centers on the conversion of acetyl-CoA to succinate for the synthesis of carbohydrates. | The glyoxylate cycle, a variation of the [[tricarboxylic acid cycle]], is an anabolic pathway occurring in plants, bacteria, protists, and fungi. The glyoxylate cycle centers on the conversion of acetyl-CoA to succinate for the synthesis of carbohydrates. | ||
| - | The glyoxylate cycle uses | + | The glyoxylate cycle uses six of the eight enzymes associated with the tricarboxylic acid cycle: citrate synthase, aconitase, succinate dehydrogenase, fumarase, and malate dehydrogenase. |
| + | |||
| + | 1) [[Citrate Synthase]] | ||
| + | |||
| + | 4C <scene name='43/430893/Cv/3'>oxaloacetate</scene> to a 6C molecule <scene name='43/430893/Cv/4'>citrate</scene> | ||
| + | |||
| + | 2) [[Aconitase]] | ||
| + | |||
| + | 6C Citrate => 6C <scene name='43/430893/Cv/5'>cis-Aconitate</scene> | ||
| + | |||
| + | 6C ''cis''-Aconitate => 6C <scene name='43/430893/Cv/6'>Isocitrate</scene> | ||
| + | |||
| + | 3) [[Succinate Dehydrogenase]] | ||
| + | |||
| + | <scene name='43/430893/Cv/10'>Succinate</scene> => <scene name='43/430893/Cv/11'>Fumarate</scene> | ||
| + | |||
| + | |||
| + | |||
| + | The two cycles differ in that in the glyoxylate cycle, isocitrate is converted into <scene name='93/939250/Cv/1'>glyoxylate</scene> and succinate by isocitrate lyase (ICL) instead of into α-ketoglutarate. | ||
*[[Malate synthase]] | *[[Malate synthase]] | ||
Revision as of 12:57, 28 November 2022
| |||||||||||
