1j74

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{{STRUCTURE_1j74| PDB=1j74 | SCENE= }}
{{STRUCTURE_1j74| PDB=1j74 | SCENE= }}
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'''Crystal Structure of Mms2'''
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===Crystal Structure of Mms2===
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==Overview==
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The ubiquitin conjugating enzyme complex Mms2-Ubc13 plays a key role in post-replicative DNA repair in yeast and the NF-kappaB signal transduction pathway in humans. This complex assembles novel polyubiquitin chains onto yet uncharacterized protein targets. Here we report the crystal structure of a complex between hMms2 (Uev1) and hUbc13 at 1.85 A resolution and a structure of free hMms2 at 1.9 A resolution. These structures reveal that the hMms2 monomer undergoes a localized conformational change upon interaction with hUbc13. The nature of the interface provides a physical basis for the preference of Mms2 for Ubc13 as a partner over a variety of other structurally similar ubiquitin-conjugating enzymes. The structure of the hMms2-hUbc13 complex provides the conceptual foundation for understanding the mechanism of Lys 63 multiubiquitin chain assembly and for its interactions with the RING finger proteins Rad5 and Traf6.
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(as it appears on PubMed at http://www.pubmed.gov), where 11473255 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11473255}}
==About this Structure==
==About this Structure==
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[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
[[Category: Uev]]
[[Category: Uev]]
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Revision as of 11:34, 1 July 2008

Image:1j74.png

Template:STRUCTURE 1j74

Crystal Structure of Mms2

Template:ABSTRACT PUBMED 11473255

About this Structure

1J74 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13., Moraes TF, Edwards RA, McKenna S, Pastushok L, Xiao W, Glover JN, Ellison MJ, Nat Struct Biol. 2001 Aug;8(8):669-73. PMID:11473255

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