1j7e

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{{STRUCTURE_1j7e| PDB=1j7e | SCENE= }}
{{STRUCTURE_1j7e| PDB=1j7e | SCENE= }}
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'''A Structural Basis for the Unique Binding Features of the Human Vitamin D-binding Protein'''
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===A Structural Basis for the Unique Binding Features of the Human Vitamin D-binding Protein===
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==Overview==
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The human serum vitamin D-binding protein (DBP) has many physiologically important functions, ranging from transporting vitamin D3 metabolites, binding and sequestering globular actin and binding fatty acids to functioning in the immune system. Here we report the 2.3 A crystal structure of DBP in complex with 25-hydroxyvitamin D3, a vitamin D3 metabolite, which reveals the vitamin D-binding site in the N-terminal part of domain I. To more explicitly explore this, we also studied the structure of DBP in complex with a vitamin D3 analog. Comparisons with the structure of human serum albumin, another family member, reveal a similar topology but also significant differences in overall, as well as local, folding. These observed structural differences explain the unique vitamin D3-binding property of DBP.
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(as it appears on PubMed at http://www.pubmed.gov), where 11799400 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11799400}}
==About this Structure==
==About this Structure==
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[[Category: Vitamin d binding]]
[[Category: Vitamin d binding]]
[[Category: Vitamin d3 analogue]]
[[Category: Vitamin d3 analogue]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:52:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:34:58 2008''

Revision as of 11:35, 1 July 2008

Image:1j7e.png

Template:STRUCTURE 1j7e

A Structural Basis for the Unique Binding Features of the Human Vitamin D-binding Protein

Template:ABSTRACT PUBMED 11799400

About this Structure

1J7E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A structural basis for the unique binding features of the human vitamin D-binding protein., Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C, Nat Struct Biol. 2002 Feb;9(2):131-6. PMID:11799400

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