1j7v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1j7v.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1j7v.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1j7v| PDB=1j7v | SCENE= }}
{{STRUCTURE_1j7v| PDB=1j7v | SCENE= }}
-
'''HUMAN IL-10 / IL-10R1 COMPLEX'''
+
===HUMAN IL-10 / IL-10R1 COMPLEX===
-
==Overview==
+
<!--
-
Interleukin 10 (IL-10) is a dimeric cytokine that plays a central role in suppressing inflammatory responses. These activities are dependent on the interaction of IL-10 with its high-affinity receptor (IL-10R1). This intermediate complex must subsequently recruit the low-affinity IL-10R2 chain before cell signaling can occur. Here we report the 2.9 A crystal structure of IL-10 bound to a soluble form of IL-10R1 (sIL-10R1). The complex consists of two IL-10s and four sIL-10R1 molecules. Several residues in the IL-10/sIL-10R1 interface are conserved in all IL-10 homologs and their receptors. The data suggests that formation of the active IL-10 signaling complex occurs by a novel molecular recognition paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on IL-10.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11485736}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11485736 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11485736}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Cytokine receptor complex]]
[[Category: Cytokine receptor complex]]
[[Category: Interleukin-10]]
[[Category: Interleukin-10]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:53:46 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:36:35 2008''

Revision as of 11:36, 1 July 2008

Image:1j7v.png

Template:STRUCTURE 1j7v

HUMAN IL-10 / IL-10R1 COMPLEX

Template:ABSTRACT PUBMED 11485736

About this Structure

1J7V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site., Josephson K, Logsdon NJ, Walter MR, Immunity. 2001 Jul;15(1):35-46. PMID:11485736

Page seeded by OCA on Tue Jul 1 14:36:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1j7v"
Personal tools