1j86

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{{STRUCTURE_1j86| PDB=1j86 | SCENE= }}
{{STRUCTURE_1j86| PDB=1j86 | SCENE= }}
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'''HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), MONOCLINIC CRYSTAL FORM 2'''
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===HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), MONOCLINIC CRYSTAL FORM 2===
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==Overview==
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We have solved the structure of the human high affinity IgE receptor, Fc epsilon RI alpha, in six different crystal forms, showing the structure in 15 different chemical environments. This database of structures shows no change in the overall shape of the molecule, as the angle between domains 1 and 2 (D1 and D2) varies little across the ensemble. However, the receptor has local conformational variability in the C' strand of D2 and in the BC loop of D1. In every crystal form, a residue inserts between tryptophan residues 87 and 110, mimicking the position of a proline from the IgE ligand. The different crystal forms reveal a distribution of carbohydrates lining the front and back surfaces of the structure. An analysis of crystal contacts in the different forms indicates regions where the molecule interacts with other proteins, and reveals a potential new binding site distal to the IgE binding site. The results of this study point to new directions for the design of molecules to inhibit the interaction of Fc epsilon RI alpha with its natural ligand and thus to prevent a primary step in the allergic response.
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The line below this paragraph, {{ABSTRACT_PUBMED_11531339}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11531339 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11531339}}
==About this Structure==
==About this Structure==
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[[Category: Ige receptor]]
[[Category: Ige receptor]]
[[Category: Immune system]]
[[Category: Immune system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:54:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 14:37:23 2008''

Revision as of 11:37, 1 July 2008

Image:1j86.png

Template:STRUCTURE 1j86

HUMAN HIGH AFFINITY FC RECEPTOR FC(EPSILON)RI(ALPHA), MONOCLINIC CRYSTAL FORM 2

Template:ABSTRACT PUBMED 11531339

About this Structure

1J86 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms., Garman SC, Sechi S, Kinet JP, Jardetzky TS, J Mol Biol. 2001 Aug 31;311(5):1049-62. PMID:11531339

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